Research Area A: Molecular basis of selective autophagy

A01 Structural investigation of the interaction of domains involved in autophagy and their regulation by post-translational modifications Volker Dötsch & Stefan Knapp
A02 Systemic analysis of autophagy degradome Christian Behrends
A03 BAG3-mediated selective macroautophagy and its modulation Christian Behl
A04 Regulatory interplay between autophagosomal and endosomal pathways Ivan Dikic
A05 Regulation of autophagy by deubiquitylating enzymes Anja Bremm

Research Area B: Functional characterization of selective autophagy

B01 Autophagy in ribosome biogenesis and quality control Stefan Müller
B02 Autophagy in the cellular response to genotoxic stress Petra Beli
B03 Evolution of autophagy and role in aging and development Heinz D. Osiewacz
B04 Crosstalk between autophagy, apoptosis, and mitochondrial dynamics during development and tumorigenesis Christian Pohl
B05 Protein engineering of sensors and modulators of autophagy Andreas Ernst
B06 Mitophagy induction by the mitochondrial unfolded protein response Münch Christian

Research Area C: Selective autophagy in human disease models

C01 Autophagy as a host defense mechanism against bacterial infections Ivan Dikic
C02 Regulation of autophagy in pathogen-induced and sterile inflammation Liliana Schaefer
C03 Crosstalk of autophagy and inflammatory signaling pathways during acute intestinal inflammation Florian Greten
C05 The selective autophagy receptors p62 and CBL in normal and malignant hematopoiesis Christian Brandts
C06 Deciphering the role of autophagy in activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL) Thomas Oellerich & Hubert Serve
C07 Molecular targeting of autophagy in glioblastoma Simone Fulda & Donat Kögel

Scientific service project

Z01 Quantitative autophagy proteomics platform Christian Behrends & Petra Beli Georg Speyer Haus Institut für Molekulare Biologie Johannes Gutenberg-Universität Mainz