Steering committee
D04
Selective autophagy OF MITOCHONDRIA AND PEROXISOMES IN ORGANISMIC AGING AND DEVELOPMENT
In this project we use the two well-established model organisms Podospora anserina and Caenorhabditis elegans to elaborate the impact of mitophagy and pexophagy on organismic aging and development. We put special emphasis on the role of membrane trafficking factors such as sorting nexins, the Rab GTPase Rab7L1/GLO-1, and the dynamin-related protein DNM1/DRP-1 for these two forms of selective autophagy.
Role and interactions of mitochondria and peroxisomes in cellular energy metabolism, signaling and aging. The organelle-dependent pathways in energy transduction result in the generation of ROS which serve as signal and induce stress responses resulting in increased lifespan (hormesis). After passing certain threshold levels ROS are deleterious and lead to accelerated aging.
Principal Investigators
Prof. Dr. stefan eimer
Institut für Zellbiologie und Neurowissenschaften
GU Frankfurt
Max-von-Laue-Str. 13
60438 Frankfurt a. M.
Germany
Office: +49 (0)69-798 42012
eimer@bio.uni-frankfurt.de
Principal Investigators
Prof. Dr. Heinz D. Osiewacz
Institut für Molekulare Biowissenschaften
Goethe Universität Frankfurt
Max-von-Laue-Str. 9
60438 Frankfurt a. M.
Germany
Office: +49 69 79 82-92 64
osiewacz@bio.uni-frankfurt.de