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PUBLICATIONS

2023

 

González A., Covarrubias-Pinto, A., Bhaskara, R.M., Glogger, M., Kuncha, S.K., Xavier, A., Seemann, E., Misra, M., Hoffmann, M.E., Bräuning, B., Balakrishnan, A., Qualmann, B., Dötsch, V., Schulman, B.A., Kessels, M.M., Hübner, C.A., Heilemann, M., Hummer, G., Dikic, I. (2023) Ubiquitination regulates ER-phagy and remodeling of the endoplasmic reticulum (in press) Nature

Körschgen H, Baeken M, Schmitt D, Nagel H, Behl C. Co-chaperone BAG3 enters autophagic pathway via its interaction with microtubule associated protein 1 light chain 3 beta. Traffic. 2023 Sep 1. doi: 10.1111/tra.12916. Epub ahead of print. 

 

Körschgen H, Behl C. Aggresome-aggrephagy transition process: getting closer to the functional roles of HDAC6 and  BAG3. Neural Regeneration Research. 2024 June; 19(6):p 1181-1182. doi:  10.4103/1673-5374.386407

Nalbach, K., Schifferer, M., Bhattacharya, D., Ho-Xuan, H., Tseng, W., Williams, L. A., Stolz, A., Lichtenthaler, S. F., Elazar, Z., & Behrends, C. (2023). Spatial proteomics reveals secretory pathway disturbances caused by neuropathy-associated TECPR2. Nature communications, 14(1), 870. https://doi.org/10.1038/s41467-023-36553-6

Pham TNM, Perumal N, Manicam C, Basoglu M, Eimer S, Fuhrmann DC, Pietrzik CU, Clement AM, Körschgen H, Schepers J, Behl C. Adaptive responses of neuronal cells to chronic endoplasmic reticulum (ER) stress. Redox Biol. 2023 Nov;67:102943. doi: 10.1016/j.redox.2023.102943. Epub 2023 Oct 20. 

Sanchez-Martin, P., Kriegenburg, F., Alves, L., Adam, J., Elsaesser, J., Babic, R., Mancilla, H., Licheva, M., Tascher, G., Munch, C., Eimer, S., & Kraft, C. (2023). ULK1-mediated phosphorylation regulates the conserved role of YKT6 in autophagy. J Cell Sci. https://doi.org/10.1242/jcs.260546

 

Schüssele, D. S., Haller, P. K., Haas, M. L., Hunter, C., Sporbeck, K., & Proikas-Cezanne, T. (2023). Autophagy profiling in single cells with open source CellProfiler-based image analysis. Autophagy, 19(1), 338–351. https://doi.org/10.1080/15548627.2022.2065617

Sutandy, F.X.R., Goessner, I., Tascher, G., Münch, C. (2023). A cytosolic surveillance mechanism activates the mitochondrial UPR. Nature (accepted)


 

2022

 

Baeken, M. W., & Behl, C. (2022). On the origin of BAG(3) and its consequences for an expansion of BAG3’s role in protein homeostasis. Journal of cellular biochemistry, 123(1), 102–114. https://doi.org/10.1002/jcb.29925

 

Bata, N., Chaikuad, A., Bakas, N. A., Limpert, A. S., Lambert, L. J., Sheffler, D. J., Berger, L. M., Liu, G., Yuan, C., Wang, L., Peng, Y., Dong, J., Celeridad, M., Layng, F., Knapp, S., & Cosford, N. D. P. (2022). Inhibitors of the Hippo Pathway Kinases STK3/MST2 and STK4/MST1 Have Utility for the Treatment of Acute Myeloid Leukemia. Journal of medicinal chemistry, 65(2), 1352–1369. https://doi.org/10.1021/acs.jmedchem.1c00804

 

Bieber, A., Capitanio, C., Erdmann, PS., Fiedler, F., Beck, F., Lee, CW., Li, D., Hummer, G., Schulman, BA., Baumeister, W., Wilfling, F. (2022). In situ structural analysis reveals membrane shape transitions during autophagosome formation. Proc. Natl. Acad. Sci. U.S.A. 119, e2209823119. https://doi.org/10.1073/pnas.2209823119

 

Denk, D., Petrocelli, V., Conche, C., Drachsler, M., Ziegler, P. K., Braun, A., Kress, A., Nicolas, A. M., Mohs, K., Becker, C., Neurath, M. F., Farin, H. F., Buchholz, C. J., Andreux, P. A., Rinsch, C., & Greten, F. R. (2022). Expansion of T memory stem cells with superior anti-tumor immunity by Urolithin A-induced mitophagy. Immunity, 55(11), 2059–2073.e8. https://doi.org/10.1016/j.immuni.2022.09.014

 

Denk, D., & Greten, F. R. (2022). Inflammation: the incubator of the tumor microenvironment. Trends in cancer, 8(11), 901–914. https://doi.org/10.1016/j.trecan.2022.07.002

 

Di Lorenzo, G., G., Iavarone, F., Maddaluno, M., Plata-Gómez, A. B., Aureli, S., Quezada Meza, C. P., Cinque, L., Palma, A., Reggio, A., Cirillo, C., Sacco, F., Stolz, A., Napolitano, G., Marin, O., Pinna, L. A., Ruzzene, M., Limongelli, V., Efeyan, A., Grumati, P., & Settembre, C. (2022). Phosphorylation of FAM134C by CK2 controls starvation-induced ER-phagy. Science Advances, 8 (35). Doi: 10.1126/sciadv.abo1215

 

Glogger, M., Wang, D., Kompa, J., Balakrishnan, A., Hiblot, J., Barth, H. D., Johnsson, K., & Heilemann, M. (2022). Synergizing Exchangeable Fluorophore Labels for Multitarget STED Microscopy. ACS nano, 16(11), 17991–17997. https://doi.org/10.1021/acsnano.2c07212

 

Gubas, A., & Dikic, I. (2022a). A guide to the regulation of selective autophagy receptors. FEBS Journal, 289(1), 75–89. https://doi.org/10.1111/febs.15824

 

Gubas, A., & Dikic, I. (2022b). ER remodeling via ER-phagy. In Molecular Cell (Vol. 82, Issue 8, pp. 1492–1500). Mol Cell. https://doi.org/10.1016/j.molcel.2022.02.018

 

Hertel, A., Alves, L. M., Dutz, H., Tascher, G., Bonn, F., Kaulich, M., Dikic, I., Eimer, S., Steinberg, F., & Bremm, A. (2022). USP32-regulated LAMTOR1 ubiquitination impacts mTORC1 activation and autophagy induction. Cell reports, 41(10), 111653. https://doi.org/10.1016/j.celrep.2022.111653

 

 

Jandl, K., Mutgan, A. C., Eller, K., Schaefer, L., & Kwapiszewska, G. (2022). The basement membrane in the cross-roads between the lung and kidney. Matrix Biol, 105, 31-52. https://doi.org/10.1016/j.matbio.2021.11.003

 

Koschade, S. E., Tascher, G., Parmar, B. S., Brandts, C. H., & Münch, C. (2022). SpinTip: A Simple, Robust, and Versatile Preanalytical Method for Microscale Suspension Cell Proteomics. Journal of proteome research, 21(11), 2827–2835. https://doi.org/10.1021/acs.jproteome.2c00478

 

 

Koschade, S. E., Klann, K., Shaid, S., Vick, B., Stratmann, J. A., Thölken, M., Meyer, L. M., Nguyen, T. D., Campe, J., Moser, L. M., Hock, S., Baker, F., Meyer, C. T., Wempe, F., Serve, H., Ullrich, E., Jeremias, I., Münch, C., & Brandts, C. H. (2022). Translatome proteomics identifies autophagy as a resistance mechanism to on-target FLT3 inhibitors in acute myeloid leukemia. Leukemia, 36(10), 2396–2407. https://doi.org/10.1038/s41375-022-01678-y

 

Merline, R., Rodig, H., Zeng-Brouwers, J., Poluzzi, C., Tascher, G., Michaelis, J., Lopez-Mosqueda, J., Rhiner, A., Huber, L. S., Diehl, V., Dikic, I., Kogel, D., Munch, C., Wygrecka, M., & Schaefer, L. (2022). A20 binding and inhibitor of nuclear factor kappa B (NF-kappaB)-1 (ABIN-1) - a novel modulator of mitochondrial autophagy. Am J Physiol Cell Physiol. https://doi.org/10.1152/ajpcell.00493.2022

 

 

Michaelis, J. B., Brunstein, M. E., Bozkurt, S., Alves, L., Wegner, M., Kaulich, M., Pohl, C., & Münch, C. (2022). Protein import motor complex reacts to mitochondrial misfolding by reducing protein import and activating mitophagy. Nature communications, 13(1), 5164. https://doi.org/10.1038/s41467-022-32564-x

 

Mukherjee, R., & Dikic, I. (2022). Regulation of Host-Pathogen Interactions via the Ubiquitin System. In Annual review of microbiology (Vol. 76, pp. 211–233). Annu Rev Microbiol. https://doi.org/10.1146/annurev-micro-041020-025803

 

Remy, J., Linder, B., Weirauch, U., Day, B. W., Stringer, B. W., Herold-Mende, C., Aigner, A., Krohn, K., & Kogel, D. (2022). STAT3 Enhances Sensitivity of Glioblastoma to Drug-Induced Autophagy-Dependent Cell Death. Cancers (Basel), 14(2). https://doi.org/10.3390/cancers14020339

 

Schäfer, J. A., Bozkurt, S., Michaelis, J. B., Klann, K., & Münch, C. (2022). Global mitochondrial protein import proteomics reveal distinct regulation by translation and translocation machinery. Molecular cell, 82(2), 435–446.e7. https://doi.org/10.1016/j.molcel.2021.11.004

 

Schmitt, D., Bozkurt, S., Henning-Domres, P., Huesmann, H., Eimer, S., Bindila, L., Behrends, C., Boyle, E., Wilfling, F., Tascher, G., Münch, C., Behl, C., & Kern, A. (2022). FACS-mediated isolation of native autophagic vesicles. Autophagy. https://doi.org/10.1080/15548627.2022.2151188

 

Schmitt, D., Bozkurt, S., Henning-Domres, P., Huesmann, H., Eimer, S., Bindila, L., Behrends, C., Boyle, E., Wilfling, F., Tascher, G., Münch, C., Behl, C., & Kern, A. (2022). Lipid and protein content profiling of isolated native autophagic vesicles. EMBO Rep, 23(12): e53065. https://doi.org/10.15252/embr.202153065

 

Schürmanns, L., Hamann, A., Osiewacz, H.D. (2022). Lifespan increase of Podospora anserina by oleic acid is linked to alterations in energy metabolism, membrane trafficking and autophagy. Cells, 11 (3), 519. doi: 10.3390/cells11030519

 

Seibert M, Kurrle N, Stolp V, Nuernberger H, Tzschentke S, Boerner L, Wempe F, Serve H, Schnuetgen F (2022) Selection-free endogenous tagging of cell lines by bicistronic co-expression of the surface antigen NGFR. MethodsX. 9:101929. https://doi.org/10.1016/j.mex.2022.101929

 

Siebert, A., Gattringer, V., Weishaupt, J. H., & Behrends, C. (2022). ALS-linked loss of Cyclin-F function affects HSP90. Life science alliance, 5(12), e202101359. https://doi.org/10.26508/lsa.202101359.

 

Stelzl, LS., Pietrek, LM., Holla, A., Oroz, J., Sikora, M., Köfinger, J., Schuler, B., Zweckstetter, M., Hummer, G. (2022). Global structure of the intrinsically disordered protein tau emerges from its local structure. JACS Au 2: 673-686. https://doi.org/10.1021/jacsau.1c00536

 

Strohm, L., Hu, Z., Suk, Y., Rühmkorf, A., Sternburg, E., Gattringer, V., Riemenschneider, H., Berutti, R., Graf, E., Weishaupt, J. H., Brill, M. S., Harbauer, A. B., Dormann, D., Dengjel, J., Edbauer, D., & Behrends, C. (2022). Multi-omics profiling identifies a deregulated FUS-MAP1B axis in ALS/FTD-associated UBQLN2 mutants. Life science alliance, 5(11), e202101327. https://doi.org/10.26508/lsa.202101327

 

Tomaskovic, I., Gonzalez, A. & Dikic, I. (2022). Ubiquitin and Legionella: From bench to bedside. Seminars in Cell and Developmental Biology. https://doi.org/10.1016/J.SEMCDB.2022.02.008

 

Tiku, V., Kew, C., Kofoed, E. M., Peng, Y., Dikic, I. & Tan, M. W. (2022). Acinetobacter baumannii Secretes a Bioactive Lipid That Triggers Inflammatory Signaling and Cell Death. Frontiers in Microbiology, 13. https://doi.org/10.3389/FMICB.2022.870101/FULL

 

Warnsmann, V., Marschall, L. M., Meeßen, A. C., Wolters, M., Schürmanns, L., Basoglu, M., Eimer, S., & Osiewacz, H. D. (2022). Disruption of the MICOS complex leads to an aberrant cristae structure and an unexpected, pronounced lifespan extension in Podospora anserina. Journal of cellular biochemistry, 123(8), 1306–1326. https://doi.org/10.1002/jcb.30278

 

Zhou, D., Borsa, M., Puleston, D. J., Zellner, S., Capera, J., Sanderson, S., Schifferer, M., Hester, S. S., Ge, X., Fischer, R., Jostins, L., Behrends, C., Alsaleh, G., & Simon, A. K. (2022). Mapping autophagosome contents identifies interleukin-7 receptor-α as a key cargo modulating CD4+ T cell proliferation. Nature communications, 13(1), 5174. https://doi.org/10.1038/s41467-022-32718-x

Heinz D, Krotova E, Hamann A, Osiewacz HD. 2021. Simultaneous Ablation of the Catalytic AMPK α-Subunit SNF1 and Mitochondrial Matrix Protease CLPP Results in Pronounced Lifespan Extension. Front Cell Dev Biol. vol.9, 259. https://doi.org/10.3389/fcell.2021.616520

2021

Baker, F., Polat, I. H., Abou-El-Ardat, K., Alshamleh, I., Thoelken, M., Hymon, D., Gubas, A., Koschade, S. E., Vischedyk, J. B., Kaulich, M., Schwalbe, H., Shaid, S., & Brandts, C. H. (2021). Metabolic Rewiring Is Essential for AML Cell Survival to Overcome Autophagy Inhibition by Loss of ATG3. Cancers, 13(23), 6142. https://doi.org/10.3390/cancers13236142

 

Basic, M., Hertel, A., Bajdzienko, J., Bonn, F., Tellechea, M., Stolz, A., Kern, A., Behl, C., & Bremm, A. (2021). The deubiquitinase USP11 is a versatile and conserved regulator of autophagy. The Journal of biological chemistry, 297(5), 101263. https://doi.org/10.1016/j.jbc.2021.101263

 

Diehl, V., Wegner, M., Grumati, P., Husnjak, K., Schaubeck, S., Gubas, A., Shah, V. J., Polat, I. H., Langschied, F., Prieto-Garcia, C., Müller, K., Kalousi, A., Ebersberger, I., Brandts, C. H., Dikic, I., & Kaulich, M. (2021). Minimized combinatorial CRISPR screens identify genetic interactions in autophagy. Nucleic acids research, 49(10), 5684–5704. https://doi.org/10.1093/nar/gkab309

 

Glogger, M., Spahn, C., Enderlein, J., & Heilemann, M. (2021). Multi-Color, Bleaching-Resistant Super-Resolution Optical Fluctuation Imaging with Oligonucleotide-Based Exchangeable Fluorophores. Angewandte Chemie (International ed. In English), 60(12), 6310–6313. https://doi.org/10.1002/anie.202013166

 

Hahn, M., Covarrubias-Pinto, A., Herhaus, L., Satpathy, S., Klann, K., Boyle, K. B., Münch, C., Rajalingam, K., Randow, F., Choudhary, C., & Dikic, I. (2021). SIK2 orchestrates actin-dependent host response upon Salmonella infection. Proceedings of the National Academy of Sciences, 118(19). https://doi.org/10.1073/pnas.2024144118

 

Herhaus L. (2021). TBK1 (TANK-binding kinase 1)-mediated regulation of autophagy in health and disease. Matrix biology : journal of the International Society for Matrix Biology, 100-101, 84–98. https://doi.org/10.1016/j.matbio.2021.01.004

 

Heinz, D., Krotova, E., Hamann, A., Osiewacz, H.D. (2021). Simultaneous ablation of the catalytic AMPK -subunit SNF1 and mitochondrial matrix protease CLPP results in pronounced lifespan extension. Front Cell Dev Biol, 9, 259. doi: 10.3389/fcell.2021.616520

 

Ho, N.T., Siggel, M., Camacho, K.V., Bhaskara, R.M., Hicks, J.M., Yao, Y., Zhang, Y., Köfinger, J., Hummer, G., & Noy, A. (2021). Membrane fusion and drug delivery with carbon nanotube porins. Proc Natl Acad Sci USA,118(19): e2016974118. https://doi.org/10.1073/pnas.2016974118

 

Juretschke, T., & Beli, P. (2021). Causes and consequences of DNA damage-induced autophagy. Matrix biology : journal of the International Society for Matrix Biology, 100-101, 39–53. https://doi.org/10.1016/j.matbio.2021.02.004.

 

Liu, Y., Mukherjee, R., Bonn, F., Colby, T., Matic, I., Glogger, M., Heilemann, M., & Dikic, I. (2021). Serine-ubiquitination regulates Golgi morphology and the secretory pathway upon Legionella infection. Cell Death and Differentiation, 28(10), 2957–2969. https://doi.org/10.1038/s41418-021-00830-y

 

Meyer, N., Henkel, L., Linder, B., Zielke, S., Tascher, G., Trautmann, S., Geisslinger, G., Munch, C., Fulda, S., Tegeder, I., & Kogel, D. (2021). Autophagy activation, lipotoxicity and lysosomal membrane permeabilization synergize to promote pimozide- and loperamide-induced glioma cell death. Autophagy, 17(11), 3424-3443. https://doi.org/10.1080/15548627.2021.1874208

 

 

Osiewacz, H.D., Schürmanns, L. (2021). A network of pathways controlling cellular homeostasis affects the onset of senescence in Podospora anserina. J Fungi, 7, 263. doi: 10.3390/jof7040263.

 

Roedig, J., Kowald, L., Juretschke, T., Karlowitz, R., Ahangarian Abhari, B., Roedig, H., Fulda, S., Beli, P., & van Wijk, S. J. (2021). USP22 controls necroptosis by regulating receptor-interacting protein kinase 3 ubiquitination. EMBO reports, 22(2), e50163. https://doi.org/10.15252/embr.202050163

 

Schaefer, L., & Dikic, I. (2021). Autophagy: Instructions from the extracellular matrix. Matrix Biol, 100-101, 1-8. https://doi.org/10.1016/j.matbio.2021.06.002

 

Seibert M, Kurrle N, Schnuetgen F, Serve H (2021) Amino acid sensory complex proteins in mTORC1 and macroautophagy regulation. Matrix Biol. 100-101:65-83. https://doi.org/10.1016/j.matbio.2021.01.001

 

Siggel, M., Bhaskara, RM., Moesser, MK., Dikic, I., Hummer, G. (2021). FAM134B-RHD protein clustering drives spontaneous budding of asymmetric membranes. J. Phys. Chem. Lett. 2021, 12, 1926-1931. https://doi.org/10.1021/acs.jpclett.1c00031

 

Warnsmann, V., Marschall, L-M., Osiewacz, H.D.(2021). Impaired F1Fo-ATP-synthase dimerization leads to the induction of cyclophilin D-mediated autophagy-dependent cell death and accelerated aging. Cells, 10, 757. doi: 10.3390/cells10040757

 

Zellner, S., Schifferer, M., & Behrends, C. (2021). Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling. Molecular cell, 81(6), 1337–1354.e8. https://doi.org/10.1016/j.molcel.2021.01.009

 

Zein, L., Fulda, S., Kogel, D., & van Wijk, S. J. L. (2021). Organelle-specific mechanisms of drug-induced autophagy-dependent cell death. Matrix Biol, 100-101, 54-64. https://doi.org/10.1016/j.matbio.2020.12.003

 

Zielke, S., Kardo, S., Zein, L., Mari, M., Covarrubias-Pinto, A., Kinzler, M. N., Meyer, N., Stolz, A., Fulda, S., Reggiori, F., Kogel, D., & van Wijk, S. (2021). ATF4 links ER stress with reticulophagy in glioblastoma cells. Autophagy, 17(9), 2432-2448. https://doi.org/10.1080/15548627.2020.1827780

2020

Barz S, Kriegenburg F, Henning A, Bhattacharya A, Mancilla H, Sánchez-Martín P, & Kraft C. 2020. Atg1 kinase regulates autophagosome-vacuole fusion by controlling SNARE bundling. EMBO reports, 21(12), e51869.

Eickhorst C, Licheva M, Kraft C. 2020. Scaffold proteins in bulk and selective autophagy. Prog Mol Biol Transl Sci. 2020;172:15-35.

Glogger M, Spahn C, Enderlein J, Heilemann M. 2020. Multi-Color, Bleaching-Resistant Super-Resolution Optical Fluctuation Imaging with Oligonucleotide-based Exchangeable Fluorophores. Angew Chem Int Ed Engl. https://doi.org/10.1002/anie.202013166

Henkel V, Schürmanns L, Brunner M, Hamann A, Osiewacz HD. 2020. Role of sorting nexin PaATG24 in autophagy, aging and development of Podospora anserina. Mech Aging Dev, 186:111211

Hollenstein DM, Kraft C. 2020. Autophagosomes are formed at a distinct cellular structure. Curr Opin Cell Biol. 2020;65:50-57.

Kern A, Behl C. 2020. On-demand autophagic network adaptations upon limited lipid availability. Autophagy, 16:7, 1348-1350

Kinzler MN, Zielke S, Kardo S, Meyer N, Kögel D, van Wijk SJL, Fulda S. 2020. STF-62247 and pimozide induce autophagy and autophagic cell death in mouse embryonic fibroblasts. Sci Rep 10, 687

Kögel D, Linder B, Brunschweiger A, Chines S, Behl C. 2020. At the Crossroads of Apoptosis and Autophagy: Multiple Roles of the Co-Chaperone BAG3 in Stress and Therapy Resistance of Cancer. Cells, 9(3), 574.

Steinberg R, Origi A, Natriashvili A, Sarmah P, Licheva M, Walker PM, Kraft C, High S, Luirink J, Shi WQ, Helmstädter M, Ulbrich MH, Koch HG. 2020. Posttranslational insertion of small membrane proteins by the bacterial signal recognition particle. PLoS Biol. 18(9), e3000874.

Wesch N, Kirkin V, Rogov V.V. 2020. Atg8-Family Proteins-Structural Features and Molecular Interactions in Autophagy and Beyond. Cells, 9:9, E2008

Wiechmann S, Maisonneuve P, Grebbin BM, Hoffmeister M, Kaulich M, Clevers H, Rajalingam K, Kurinov I, Farin HF, Sicheri F, Ernst A. 2020. Conformation-specific inhibitors of activated Ras GTPases reveal limited Ras dependency of patient-derived cancer organoids. J Biol Chem. pii: jbc.RA119.011025.

Zein L, Fulda S, Kögel D, & van Wijk S. 2020. Organelle-specific mechanisms of drug-induced autophagy-dependent cell death. Matrix Biol. https://doi.org/10.1016/j.matbio.2020.12.003

Zielke S, Kardo S, Zein L, Mari M, Covarrubias-Pinto A, Kinzler MN, Meyer N, Stolz A, Fulda S, Reggiori F, Kögel D, van Wijk S. 2020. ATF4 links ER stress with reticulophagy in glioblastoma cells. Autophagy, 1-17

Chaikuad A, Koschade SE, Stolz A, Zivkovic K, Pohl C, Shaid S, Ren H, Lambert LJ, Cosford NDP, Brandts CH & Knapp S. 2019. Conservation of structure, function and inhibitor binding in UNC-51-like kinase 1 and 2 (ULK1/2). Biochem J, 476, 875-887.

Chakraborty D, Felzen V, Hiebel C, Stuerner E, Perumal N, Manicam C, Grus F, Wolfrum U, Behl C. 2019. Enhanced autophagic-lysosomal activity and increased BAG3-mediated selective macroautophagy as adaptive response of neuronal cells to chronic oxidative stress. Redox Biol, accepted

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