BAG3-mediated selective autophagy in neuronal protein homeostasis and neurodegeneration
Based on our previous findings, we now aim to decipher the detailed function of BAG3-mediated selective autophagy in neuronal proteostasis and neurodegeneration employing cellular models of ALS and Alzheimer´s disease. We will analyze the clearance of aggregation-prone disease proteins, define the aggresome content and the required autophagy machinery downstream of BAG3-driven aggresome formation. Further, we will elucidate the impact of upstream modulators and signaling pathways. Finally, we will analyze the relevance of BAG3-mediated autophagy for neuronal mitochondrial quality control and examine its role in mitophagy and during the adaptation of neuronal cells to redox stress.
Prof. Dr. CHristian behl
Institute for Pathobiochemistry
University Medical Center of the Johannes Gutenberg University Mainz
Office: +49 (0)6131 39-25890