top of page


Pexophagy and mitophagy in cellular homeostasis, aging and disease

Peroxisomes are highly plastic organelles involved in several metabolic processes, including fatty acid oxidation, ether lipid synthesis, and redox homeostasis. The number of peroxisomes and their activity dynamically changes in response to nutrient availability and cellular stress. Damaged or superfluous peroxisomes are removed mainly by pexophagy, the selective autophagic degradation of peroxisomes promoted by ubiquitylation of peroxisomal membrane proteins. In this collaborative project, we will investigate molecular mechanisms that control pexophagy and delineate the impact of autophagy-dependent peroxisomal quality control and dynamics on cellular homeostasis, aging and disease. In addition, we will study how the interplay between peroxisomes and mitochondria contribute to safeguarding homeostasis of both organelles. To accomplish these aims, we will combine expertise of the Eimer and Bremm groups as well as the advantages of the respectively used model systems (C. elegans and human cells).    

dr. anja bremm

Institute of Biochemistry II

GU Frankfurt
Theodor Stern Kai 7
60590 Frankfurt a. M.

Office: +49 69 6301 5450


Prof. dr. stefan eimer

Institut für Zellbiologie und Neurowissenschaften

GU Frankfurt
Max-von-Laue-Str. 13
60438 Frankfurt a. M.
Office: +49 69 798 42012

bottom of page